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Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung

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CONFLICT OF INTEREST The authors of this work declare that they have no conflicts of interest

Under physiologic conditions, nitric oxide is produced from Larginine by constitutive nitric oxide synthase (cNOS) and participates in a variety of important biological functions such as immunoregulation of inflammatory reactions, the downregulation of tumor necrosis factor (TNF) production, MHC II expression in macrophages, induction of apoptosis in CD4 cells, physiological regulation of the mitochondrial respiratory chain, inhibition of antigen presentation, and leukocyte adhesion and migration

Of particular importance was HapC, the redox sensitive subunit of the CCAAT-Binding Complex (CBC