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People with severe zinc deficiency due to malabsorption conditions such as Crohn's disease or gastric bypass surgery may require more than 50 mg per day

Follow-up care to track progress and adjust as needed

Nicotinamide and allopurinol seem to be effective in reducing the inflammation of soft tissue but the data sustaining this conclusion were obtained in a rather small sample of GO patients affected with both moderate-to-severe and mild GO ( in vitro results on the use of pentoxifylline are promising, but clinical studies provided conflicting results ( in vitro findings reported above, one can speculate that quercetin and -carotene might be the most promising, but clinical trials are needed to confirm this hypothesis

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In some cases, we employ it orally as part of our pigmentation removal programs for melasma