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In the retina, GPER activation can promote the survival of retinal neurons and enhance the function of photoreceptors, which is crucial for maintaining a normal visual capacity [114]

A 73 participant venous ulcer study demonstrated 45 percent faster healing in treated groups compared to controls

Zimmerman HJ, Maddrey WC (1995)

By shifting substrate preference toward lipid metabolism, AX supports sustained energy production during endurance activities, helps delay fatigue, and may improve overall exercise performance

Future systematic analysis of the tissue specificity and disease stage dependency of these pathways will directly impact the design of OA ferroptosis intervention strategies