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Differential diagnoses to consider Septic arthritis should be considered in patients with monoarticular joint pain, with erythema, warmth and joint immobility

Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells

Small aggregates may remain suspended and invisible