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Lack of approval reflects insufficient human clinical trial data and incomplete evaluation of risks, dosing, and long-term effects

Other peptides under investigation Several additional peptides are being studied for disc-related applications, though with less established evidence: Vasoactive Intestinal Peptide (VIP) has demonstrated the ability to slow disc degeneration progression and improve aggrecan levels in mouse studies

Patacchini R, Lecci A, Holzer P, Maggi CA

The timing of B12 supplementation is generally flexible and should be guided by personal preference and tolerability