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BPC-157 is a synthetic peptide derived from a protein in gastric juice

Rodents infused with angiotensin II had greater gut permeability as assessed by FITC-Dextran [92, 48] and decreased intestinal gene expression of tight junction proteins including ZO-1, particularly on a low fibre diet [48, 96], which was accompanied by increased intestinal expression of the inflammatory cytokines TNF- and IL-6 [96]

Any contact of the peptide with water or other solvents used in tablet production causes peptide degradation to a greater or lesser extent

Low levels have been associated with increased feelings of anxiety, irritability, and low mood

Goldstein et al