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Gut Permeability, Inflammation, and DAO Deficiency Gut permeability and inflammation can impact DAO (diamine oxidase) production and function, although they may not necessarily lead directly to a deficiency in DAO due to an excessive need for histamine metabolism

Statistical analysis No statistical methods were used to pre-determine sample sizes, but similar sample sizes were used in previous publications 15,46

TMT labeling and fractionation Desalted peptides were labeled with TMTpro reagents (Thermo Fisher Scientific)

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A similar effect can happen with other treatments such as retinoids, which may cause purging due to the way they affect how skin cells move from the lower layers to the surface (1,2)