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and c) irregular dietary patterns), reduced bioavailability (impairment of the intrinsic factor-mediated absorption pathway, often due to the widespread and prolonged use of proton pump inhibitors), and malabsorption syndromes

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Discussion Pernicious anemia (PA) is a type of megaloblastic anemia caused by cobalamin (Vitamin B12) deficiency resulting from a lack of intrinsic factor (IF)

These support the same ultimate goal through different mechanisms