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Half-Life Comparison The half-life difference between the two analogs is striking: IGF-1 LR3: Estimated half-life of ~2030 hours in biological systems IGF-1 DES: Estimated half-life of ~2030 minutes substantially longer than free native IGF-1 (~1020 min), but far shorter than IGF-1 LR3 This difference directly impacts how experiments must be structured

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Mayeda RM, Mobley TM, Weiss RE, Murchland AR, Berkman LF, Sabbath EL