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Koff, MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

BPC-157 and TB-4 are adjuncts to standard care (fiber, hydration, sitz baths, possible procedural intervention), not replacements

This manifests as blood pressure instability, digestive problems, bladder dysfunction, abnormal sweating, and sexual dysfunction

Curr Pharm Des 24:19902001 Sloan J (2008) Soft tissue injuries: introduction and basic principles

TB-500 has demonstrated neuroprotective effects in spinal cord injury models, with treated animals showing significantly more neuronal and oligodendrocyte survival