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Unfortunately, its very hard to predict when or if this will happen as there are many variables at play, but the potential of getting off methimazole is a common reason for using this bundle

10.1016/j.ypmed.2013.09.023

Jin B, Qian L, Fu X, Zhu J, Shu J

It will remain stable at room temperature for up to ten weeks, but for the best storage and results, you should store in your refrigerator, in which case it will stay stable for up to six months

18 The effect of apixaban on safety and efficacy endpoints in Phase II and III clinical trials appears to be consistent between Japanese patients and the broader population, despite potential small differences in apixaban clearance