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DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide investigated in experimental models for its involvement in sleep regulation and circadian rhythm signaling

During stress, the latent monomer of heat shock factor (HSF)-1 is rapidly converted to a trimeric form active in the nucleus to bind to the promoters of HSF-responsive heat shock genes and activate their transcription [94, 95]

A PD-L1-targeting regulator for metabolic reprogramming to enhance glutamine inhibition-mediated synergistic antitumor metabolic and immune therapy

And human studies are scarce

Glutamatergic excess can result in neurotoxic oxidative stress [28], while a concomitant elevation of GSH may provide a neuroprotective gate-keeping effect [29], thus a strong covariance may be a marker of a healthy state