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A formal analysis of cytokine networks in chronic fatigue syndrome

Gene ontology and pathway analysis revealed that 26% of CR responded DEGs are involved in malignancy and cancerassociated networks The 26% (121/467) of DEGs were characterized in IPA (Supplementary Table S5)

Melinda Faulkner In Escherichia coli, the glutathione/glutaredoxin and thioredoxin pathways are essential for the reduction of cytoplasmic protein disulfide bonds, including those formed in the essential enzyme ribonucleotide reductase during its action on substrates

This finding does not establish causality, but it is consistent with a model in which robust mitochondrial peptide signaling is a feature of successful aging rather than a peripheral correlate

They support red blood cell production, DNA synthesis, and normal nerve function when deficiency is present