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These studies have shown that T21 is associated with reduced mitochondrial structure and vascularization, as well as decreased connectivity within the mitochondrial network, when compared to normal mitochondria (Zamponi and Helguera 2019

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Autism Methylation and Autism Folinic Acid Autism Link: Understanding Cerebral Folate Deficiency MTHFR gene, Methylation, and Autism Exploring the Link References Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA