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Mechanisms of resistance to anti-angiogenic therapy Resistance to anti-angiogenic therapy is an important issue that likely explains the variable response in different types of tumors and the limited overall survival benefits

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329 Therefore, mitochondrial fission level concerns the metastasis of cancers, and the inhibiting of mitochondrial fission has the potential to be a promising target for better prognosis

Studies on Mn deficiency in humans and animals have demonstrated its essential role in reproduction, skeletal development, lipid metabolism, blood clotting, and blood glucose regulation (Powers et al., 2023