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Obeticholic acid (OCA), the most extensively studied FXR agonist, was evaluated in the FLINT trial (NCT01265498), where non-cirrhotic NASH patients receiving 25 mg daily for 72 weeks experienced notable improvements in liver histology, including reductions in steatosis, inflammation, and fibrosis [65,66,67,68]

Moreover, mice blood analysis revealed marked decreases in the population of T315I-Bcr-Abl-32D/EGFP + cells by the combination of JMF4073 with UK-5099 treatment (Fig

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