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Most of the research regarding coffee enemas derives from case reports, which typically highlight the risks of the procedure

it is estimated that 14,242,000 babies will be affected by SCD between 2010 and 2050

Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco MJ, Lotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A