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Without this signal, the body readily sacrifices muscle as part of the weight loss process, leaving men lighter but not meaningfully leaner

This model posits that during the early stages of AD, particularly in the preclinical phase, cerebral iron overloadtriggered by genetic factors (e.g., APOE 4) or agingalong with the resultant oxidative stress, constitutes a key upstream event that initiates the pathological cascade

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It's known to cause some fluid retention and increased fluid volume, which may have been related to that cardiovascular death

P = .004)