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The clinical rationale is straightforward: deliver the 5-alpha reductase inhibitor directly to the scalp to reduce local DHT while minimizing systemic absorption and its associated side effects

Thus, we hypothesize that glycine supplementation reduces hepatic steatosis and inflammation by enhancing the elimination of excess acylCoAs in the liver as acylglycines

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For instance, antibodies targeting the ER stress-related protein GRP78 have been detected in the blood of SLE patients, with increased GRP78 and XBP1 expression observed in antibody-secreting plasma cells