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The promoter (918) with ARE showed a marked reduction in young vs aged hLECs, which was directly correlated to decreased Nrf2/ARE binding

doi: 10.1016/j.semarthrit.2020.07.006 239 RobinsonGAWilkinsonMGLWincupC

Raghu and colleagues synthesized compounds derived from pyrazolo[1,5 a ] [1, 3, 5] triazine as antioxidant agents and possible inhibitors of lipoxygenase and XO