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Reported side effects in available research and clinical use include fatigue, headaches, nausea, and injection site irritation generally mild, but again, incompletely characterized over long-term use
Human dermal fibroblast studies show up to 70% increase in collagen production at optimal 1 nanomolar concentration, with collagen IV showing 25.4-fold increase when combined with hyaluronic acid
Note that the Mpro S301P and T304I substitutions overlap the P6 and P3 positions of the nsp5/nsp6 cleavage site located at the C-terminus of Mpro
Appl Microbiol Biotechnol
No lethal dose identified at doses up to 20 mg/kg in animal studies No organ toxicity observed across multiple organ systems Negative mutagenicity testing across standard assays No teratogenic effects in pregnancy studies Limited long-term human data beyond 6 weeks Theoretical Considerations The primary theoretical concern relates to BPC-157s angiogenic properties
