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Nuclear Transcription Factor Activation: Tracking the stimulation of native, cell-autonomous cytoprotective loops and anti-oxidant responses responsible for re-establishing immune homeostasis

Animals that received daily or weekly injuries showed significant cognitive impairments that remained at 1 year post injury

The blood-labyrinth-barrier (BLB), which includes a blood-endolymph barrier and a blood-perilymph barrier, consists of tight junctions between specialized epithelial cells in the labyrinth spaces (i.e., the vestibular and cochlear spaces)

The brain is particularly sensitive to ROS due to its high requirement for oxygen and the prevalence of lipid cells that are prone to peroxide damage

Blood should be collected fasting, centrifuged promptly, and stored at -80C for optimal stability