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P-gp function is found to be decreased in AD and increased in schizophrenia and epilepsy ( 11 C]Verapamil and [ 11 C]Loperamide, with others also shown in Figure 4, section 3

Mesenchymal stem cell studies demonstrate these increases occur through integrin pathways without cytotoxic effects across wide concentration ranges

Additional documented interactions include the FAK-paxillin pathway, fibroblast activity, and dopaminergic, serotonergic, and GABAergic neurotransmitter systems, though these represent a more preliminary evidence base

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In an IV setting, we can deliver high-dose Vitamin C (ranging from 500 mg to 5000 mg) that would be impossible to take orally without causing significant stomach upset