While generally safe, certain individuals should avoid AOD-9604, including: Pregnant or breastfeeding women Due to limited safety data
Vitamin B12 deficiency has been linked to fatigue, tingling or loss of feeling in the extremities, irritability, memory impairment, depression, anemia, irritable bowel syndrome (IBS), constipation, poor wound healing, dry or damaged looking skin, and neurological disorders
A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes
This feature supports extended use without rapid contamination risks
Other reported effects include headaches, dizziness, nausea, and gastrointestinal discomfort, though these are less common