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Hypothalamic IKK beta/NF-kappa B and ER stress link overnutrition to energy imbalance and obesity

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They found that gut microbiota changes, particularly the influence of Desulfovibrio and Akkermansia, along with disturbances in lipid metabolic pathways in the prefrontal cortex and hippocampus, led to the manifestation of atherosclerosis combined with depressive symptoms in the mice (172)

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