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Consequently, the NAD + /NADH imbalance propagates metabolic inflexibility, impairing neuron-glia metabolic crosstalk while dysregulating the -amino--carboxymuconate--semialdehyde decarboxylase (ACMSD)/kynurenine pathway, a critical alternate NAD + biosynthesis route [109, 110]

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92 However, this observation remains to be replicated by other studies

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