B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease
Clinical trials tested doses up to 1mg daily without significant adverse effects, but this does not mean higher doses produce better results or that exceeding researched doses is safe
A 30 mg tirzepatide vial with 3 mL of bacteriostatic water makes 10 mg/mL, where 5 mg draws 50 units and 10 mg draws 100 units
No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern
While these injections are becoming popular for those looking to enhance their health, there are questions surrounding their effectiveness