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ATP synthase c-subunit leak causes aberrant cellular metabolism in fragile X syndrome

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GPx and GST which catalyze GSH-dependent reduction of LOOH through their peroxidase activity are the major secondary defenses in the lens against ROS induced lipid peroxidation

Eur J Pharmacol 469(13):145152

Researchers confirmed this through knockout studies in mice, where animals lacking beta-3 adrenergic receptors showed zero response to AOD 9604, proving the peptide works specifically through this receptor pathway in adipose tissue