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Material and methods: The review authors independently screened and evaluated studies identified through medical databases, including PubMed, Scopus, and institutional repositories

The process of folding the stomach fundus is known as Nissen fundoplication

Thymosin Alpha-1 (T1) : This peptide boosts immune function and reduces inflammation, which could work well alongside FOXO4-DRI to improve the bodys response to aging and chronic conditions

All documented evaluations remain confined to investigational, analytical, and preclinical research models, with no application beyond laboratory-based examination

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