When IgG4-RD involves the central nervous system or surrounding areas, it may cause: Persistent headaches Eye pain or swelling Facial numbness Neurological symptoms like vision or hearing changes Chronic sinus problems These symptoms may resemble migraines, tension-type headaches, or sinus infections, which is why understanding the link between IgG4-RD and chronic headaches is essential
K.TsymbalyukO.VennekensR.GerzanichV.et al
It prevents the post-synaptic density protein 95 (PSD-95) from binding to the NR2B subunit of the NMDA receptor and the PDZ domain of neuronal nitric oxide synthase (nNOS) [8,51]
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Argument one: energy expenditure, not just energy intake
