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Another important observation of that period was made by Goldberg, who studied protein turnover in skeletal muscle of hypophysectomized rats with 3H-leucine tracer techniques

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The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2