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This hypoxic and acidic microenvironment in metabolically altered GBMs affects radiotherapy efficacy and drug delivery, and plays a crucial role in biological mechanisms involved in cancer progression and treatment resistance, such as aberrant DNA repair, angiogenesis, and cancer stem cell maintenance [5,6,7,8,9,10]

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Mitochondrial Calcium Accumulation and Respiration in Ischemic Acute Renal Failure in the Rat

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