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Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice

doi: 10.1038/nsmb.2332 139 ShangGZhangCChenZJBaiX-CZhangX

Field 5: Human evidence 5-Amino-1MQ : zero

A more recent randomized, double-blind, placebo-controlled study in 30 patients with type 2 diabetes found that intravenous infusion of 600 mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate (63)