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The anionic nature of superoxide and the fact that it is mostly produced in the mitochondrial matrix determine that the bulk of antioxidant defenses to neutralize superoxide and other ROS reside in the matrix

By acting simultaneously on GLP-1 and GIP receptors, it achieved a 20,9% weight reduction in SURMOUNT-1 (15 mg over 72 weeks), the highest result observed for a single agent before the advent of amylin combinations