The fact that wild-type ATXN3 binds to components of the transcriptional machinery in cells, as well as the transcriptional changes reported in animal models of SCA3 in the presymptomatic phase, favors the theory of a general transcriptional dysregulation as an initiating factor of SCA3 [117,118,119]
Data were analyzed using Living Image (v4.3.1)
Similarly, Brigham Buhler of Ways2Well claims to have put 75,000+ patients on peptides, across their practices, with no reported adverse events
Malaguarnera, M., Risino, C., Cammalleri, L., Malaguarnera, L., Astuto, M., Vecchio, I., and Rampello, L
doi: 10.1016/j.bbrc.2004.03.151 168 ChiXBrittECShowsHWHjelmaasAJShettySKCushingEMet al