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Crosstalk of brain and bone-clinical observations and their molecular bases

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PPAR is considered one of the master modulators of mitochondrial biogenesis and function and plays a crucial role in fat cell differentiation, lipid storage, vascular function, and energy metabolism ( Thiazolidinediones (TZDs) represent a class of compounds that are high-affinity ligands for the transcription factor PPAR (Villacorta et al., 2009)

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