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Int J Pharm Drug Res 2015;5(1):1-6

Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]

B12 deficiency can cause fatigue and poor metabolism, which can be the cause of your sudden weight gain

Related: Reduce Oxidative Stress in 4 Simple Steps NAC vs Glutathione: Which Is the Better Antioxidant

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