It has normal catalytic activity and is not associated with hemolysis (Class IV)
The main reason titanium dioxide was used to treat skin cancer was that it produces reactive oxygen species (ROS) when exposed to light or UV radiation, however, it lacks selectivity and also damages nearby healthy cells
doi: 10.1093/humupd/dmac005 106 de RouxNGeninECarelJCMatsudaFChaussainJLMilgromE
NO-agents showed a limited NO-system involvement (in the lower esophageal sphincter (but not in the pyloric sphincter), L-arginine further decreased, L-NAME further decreased, while L-NAME+L-arginine rats presented values similar to those observed in controls)
1997) and causes differential changes in expression of numerous genes associated with stress response, cell cycle, growth inhibition, cell death, cell structure, cell signalling and inflammation (Priyadarsiny et al