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Clin Exp Immunol 135: 219-225

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Folate Deficiency Avoid use of sulfamethoxazole and trimethoprim in patients with impaired renal or hepatic function, in those with possible folate deficiency (e.g., the elderly, chronic alcoholics, patients receiving anticonvulsant therapy, patients with malabsorption syndrome, and patients in malnutrition states) and in those with severe allergies or bronchial asthma

Specifically, lactylation is deposited on the activity enhancers in the NCC gene regulatory network, promoting chromatin accessibility and influencing NCC behavior like migration