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UA also induced an increase in Nrf2, a transcription factor that regulates genes involved in antioxidant response 35

Ethanols impact on GABA and glutamate systems further compounds affective dysfunction

(3) Bilic I, Zoricic I, Anic T, Separovic J, et al

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We first provide a brief background on the multi-target cardiovascular effects of TCM-derived metabolites (Figure 1), then discuss evidence for their benefits in specific disease contexts (atherosclerosis, hypertension, myocardial infarction, heart failure), integrate findings from clinical studies, and finally consider the challenges and future directions for translating these therapies into mainstream cardiovascular care