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The high metabolic demands of malignant gliomas create a hypoxic tumor microenvironment (TME), triggering a shift in tissue metabolism towards glycolysis, which ultimately leads to elevated lactate levels [144]

Our data provide mechanistic insights into how lysine acetylation of virulence factors is used to reprogram virulence adjusting it to the host cells metabolic state

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This can be exemplified in the case of homocysteine

Injectable forms remain the benchmark for consistent systemic exposure, though local or compartmental activity may be feasible for some molecules designed for oral stability