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And part of that is [01:13:00] just shared experiences together, shared state experiences, and also shared honesty and vulnerability with one another

Here are some critical considerations: 1

Additionally, neurotoxins induce nuclear fragmentation, endoplasmic reticulum (ER) stress and unfolded protein response in catecholaminergic cells, which are associated with changes in proteasomal and chaperone activities, similar to those observed in PD [45,55]

It is these poorly-understood processes involved in the transport of UA that are particularly important in determining the disposition and action of UA within the brain, but are unaccounted for in the assumptions of the MR studies