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Estrogen Metabolism Support Optimizing hepatic Phase I and Phase II estrogen detoxification reduces the burden of potentially carcinogenic estrogen metabolites (particularly 4-OH and 16-OH estrone) and may reduce estrogen-driven fibroid growth: DIM (diindolylmethane): Shifts estrogen metabolism toward the favourable 2-OH pathway Calcium-D-glucarate: Inhibits -glucuronidase, preventing deconjugation and reabsorption of estrogens in the gut (Note: off-the-shelf detox kits from health food stores are not equivalent to therapeutic doses of these specific compounds) N-acetylcysteine (NAC): Supports glutathione synthesis and Phase II sulphation 3

Annu Rev Immunol 27:147163 Del Campo JA, Gallego P, Grande L (2018Jan 27) Role of inflammatory response in liver diseases: therapeutic strategies

Breastfeeding : There is insufficient data regarding use during lactation, and the potential risks to the infant are unknown

These findings indicated that the Cys 36 residue is relevant for the glutathione peroxidase activity of S

Lactate: elucidating its indispensable role in human health