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This scenario could result from decrements in mitochondrial bioenergetics, including a decreased supply of GTP for autophagic vesicular processing

Clinical description All patients with gamma-glutamylcysteine synthetase deficiency have had hemolytic anemia, usually rather mild [18]

We also discuss the relevance of kidney function, another confounder that may alter the GH/IGF-I axis in a manner that can replicate findings seen in acromegaly

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Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers