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Downstream genes regulated by the Nrf2/ARE axis include HO-1, NQO1, and iron metabolism-related proteins (FTH1, FTL, FPN1), etc.: HO-1 degrades pro-oxidative heme to produce bilirubin with iron-chelating activity, and NQO1 directly scavenges lipid free radicals

These observations, while not formal clinical trials for acne, highlight its potential for broader skin health benefits

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In addition, the concomitant up-regulation of GSH levels in HPV-16 E7-infected cells might act synergistically to increase the concentration of reduced GSTP1