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Arterioscler Thromb 14, 19001905

LPS itself has multiple adverse effects on the gut function, promoting intestinal inflammation and disrupting tight junctions (TJ) organization via specific signaling pathways which determines directly enterocytes shedding without compensatory TJ- releasing, and induces oxidative stress in epithelial cells, mitochondrial failure, and mitophagy [22]

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The hypoxic response of tumors is dependent on their microenvironment