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Inadequate mitochondrial Asp production is an important cause of T cell dysfunction, and lack of aspartate inhibits nicotinamide purine dinucleotide (NADH) production, causing ER expansion and TNF release

and avoiding blanket supplementation in patients with adequate redox balance to prevent interference with physiological ROS signaling (Sies et al., 2024

The people with HIV were on stable antiretroviral therapy and had not been hospitalized for six months prior to the study