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found that TMAO promoted calcium/phosphate-induced calcification in the vascular smooth muscle cells of rats and human urinary system patients in a dose-dependent manner, and upregulated the expression of bone-related molecules (Runt-related transcription factor2, Runx2, and Bone morphogenetic protein-2, BMP2)

Yin Z, Ivanov V, Habelhah H, Tew KD and Ronai Z

Supports skin texture, radiance, and anti-ageing care routines

doi:10.1155/2018/2469486 72 Chang, C.-T., Hsieh, P.-J., Lee, H.-C., Lo, C.-H., Tam, K.-W

Pre-filled syringes also lack preservative protection if the dose is small enough that the preservative concentration is significantly diluted