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IRP2 expression is significantly upregulated in the midbrain substantia nigra of PD mice, increasing TFR1, FTH, and p53 levels, while decreasing SLC7A11 and GPX4 levels, leading to ferroptosis and disruption of the amino acid antioxidant system in dopaminergic neurons

Gas chromatographic-mass spectrometric analysis, antioxidant, antiproliferative and antibacterial activities of the essential oil of Prangospabularia

intermittent treatment with senolytics have conclusively reduced senescent cell burden in peripheral tissues (fat, lung, kidney, pancreas, cartilage, and muscle), improved pathologies in these tissues, and extended healthspan and lifespan (45, 46, 100-103)

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