According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment
Without a doctors input, you wont know if a low B12 test result is because of your diet, medications that you take, or a health issue
Bioorganic & Medicinal Chemistry Letters
Complete Medical Form Answer a few quick health questions to help us understand your symptoms and goals
Intermediate users commonly use 300-400 mcg daily, while advanced protocols may utilize 500 mcg daily or divided doses of 250 mcg twice per day
